Long‐term potentiation (LTP) in the hippocampus is accompanied by a number of changes on both sides of the synapse. It is now generally considered that the trigger for initiating LTP is the entry of calcium into the postsynaptic area through the NMDA‐associated channel while the mechanism(s) underlying the maintenance of LTP are less well understood and probably involve contributions from both sides of the synapse.

We propose that some aspects of language evolved to fit the brain, whereas other aspects co-evolved with the brain. Cladistic analysis indicates that common basic structures of both action and grammar arose in phylogeny six million years ago and in ontogeny before age two, with a shared prefrontal neural substrate. In contrast, mirror neurons, found in both humans and monkeys, suggest that the neural basis for intersubjectivity evolved before language. Natural selection acts upon genes controlling the neural substrates of these (...) phenotypic language functions. (shrink)

Over the past decade, interest in human enhancement has waxed and waned. The initial surge of interest and funding, driven by the US Army’s desire for a ‘Future Force Warrior’ has partly given way to the challenges of meeting operational demands abroad. However the ethical opportunities provided by soldier enhancement demand that investigation of its possibilities continue. Benefits include enhanced decision-making, improved force capability, reduced force size and lower casualty rates. These benefits — and enhancement itself — carry concomitant risks, (...) including morale issues due to tension between enhanced and unenhanced soldiers, the issues of enhanced veterans and ownership of enhanced bodies, challenges to the army’s core values and personal identity issues. A range of measures should be designed to highlight the opportunities offered by enhancement while also minimising the potential risks. This includes providing advice on which areas the army ought to demonstrate restraint in research for ethical reasons. (shrink)

In nursing, expectations of honesty and integrity are clearly stipulated throughout professional standards and codes of conduct, thus the concept of academic integrity has even more impetus in preparing students for graduate practice. However, a disparity between policy and practice misses the opportunity to instil the principles of academic integrity, and at its core honesty, a pivotal trait in the nursing profession. This study draws upon the experience of the nursing faculty to explore how academic integrity policy of deterrence operate (...) in nursing education.While participants deplored cheating behaviours, they expressed frustration in having to ‘police’ large numbers of students who had little awareness of the academic standards to meet policy requirements. In addition, they were cynical because of a perceived lack of severity in sanctions for students who repeatedly breached integrity. Participants expressed a moral obligation as educators to meet student learning needs and preferred to engage with students in a more meaningful way to uphold academic integrity. The ambivalence to detect and report breaches in integrity undermines the effectiveness of policy. Therefore, faculty must recognise the importance of their role in detecting and escalating cases of dishonesty and execute deterrence in a more consistent way. To do this, greater support at an institutional level, such as smaller class sizes, inclusion in decision making around sanctions and recognition of additional workload, will enable faculty to uphold policy. Although policing was not their preferred approach, the role of faculty in detecting and reporting cases of misconduct is crucial to increase the certainty of students getting caught, which is essential if policy is to be effective in deterring dishonest behaviour. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Sacramental Character and the Pattern of Theological Life:Medieval Context and Early Modern ReceptionReginald M. Lynch O.P.In question 63 of the tertia pars, Thomas Aquinas defines the so-called character that is conferred by certain sacraments (namely baptism, confirmation, and holy orders), as a secondary effect caused by the sacraments, with grace itself identified as the primary effect. As separated instruments of the humanity of Christ, in his mature work (...) in the Summa theologiae Aquinas argues that all Christian sacraments are perfective instrumental causes of the effect of the Incarnation in the human persons who receive them.1 As instrumental means by which these effects are conferred, therefore, for Aquinas the sapiential intelligibility of the sacraments is found in the larger sweep of sacra doctrina and the Incarnation, wherein the ratio and necessity of these larger theological themes contextualize Aquinas's understanding of the necessity of the sacraments themselves as instrumental extensions of the same.2 Taken in itself, aspects of what would later become the question of sacramental character for Scholastics first emerged as a doctrinal topic in the context of patristic debates over the permanence of the sacrament of baptism.3 In the Latin West, the influence of Augustine's distinction between the permanence of the sacramentum received in baptism and its use in charity proved to be a ubiquitous influence [End Page 1337] for later Latin theology.4 Concerning the metaphysical nature of this character, however, in both his Sentences commentary and Summa theologiae, Aquinas joins an ongoing conversation among thirteenth-century Scholastics about the utility of the Aristotelian categories for describing sacramental character. What is sacramental character specifically, and how should this be understood in relation to the wider speculative complexities of grace, the infused virtues and gifts, and beatitude? Because of continued controversy over the role of Aristotelianism in theology during the second half of the thirteenth century, many Scholastics of Aquinas's generation analyzed the quiddity of sacramental character from an Aristotelian perspective, working to describe the doctrine inherited from the Church's tradition using Aristotelian terminology. As will be shown, although some argued that sacramental character should be understood as a habitus, Aquinas argues that character is better understood as a power.The second and third sections of this article will explore the development of Scholastic accounts of the quiddity of sacramental character during the medieval and early modern periods, and the wider theological implications of these conversations. In the final analysis, it is my aim to show not only that Aquinas's account of sacramental character is intrinsically fitting on theological grounds, but that Aquinas's account of sacramental character as a qualitative power conveys and preserves the received theological tradition more effectively than the options proposed by some of his contemporaries. With these larger objectives in mind, the first section of this article serves as a necessary historical prelude—what, precisely, is at stake from the wider perspective of the Church's theological tradition in these medieval and early modern Scholastic debates? Accordingly, the first section will provide an overview of the historical development of the doctrine of sacramental character, focusing specifically on the way in which certain Augustinian doctrinal concepts and linguistic usages developed in later medieval usage and ultimately came to be incorporated into the framework of Peter Lombard's Sentences—the text that would serve as the common backdrop for the Scholastic conversations about the "quiddity" of this same doctrine.In the following, therefore, this article will begin by examining the origins of the doctrine of sacramental character in Latin theology in Augustine's baptismal theology. Building on this foundation, our attention will turn to Peter Lombard's reception of Augustine's as the context in which [End Page 1338] thirteenth-century Scholastic debates about sacramental character would develop. Although the specific metaphysical questions that Scholastics like Aquinas and Bonaventure would entertain do not form part of Augustine's approach to this issue, Lombard's particular articulation of Augustine's sacramental theology would provide the textual and conceptual backdrop against which these later Scholastic conversations would develop. Accordingly, the second section of this article will build on the first, beginning with a consideration of Aquinas... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Thomas Aquinas on the Priesthood:Temple, Allegory, and the Humanities of Christ*Reginald M. Lynch O.P.In this lecture, I will examine Aquinas's approach to the concept of priesthood and its place in the economy of salvation, drawing upon Aquinas's systematic presentation of Christ's priesthood and sacramental priesthood within the Church, as well as the figural representation of these incarnational and ecclesial realities within the liturgical world of the Mosaic covenant. (...) Theologically considered, in the context of the New Law Aquinas's notion of priesthood in the Church begins with Christ, then extending to the members of the Church in Baptism, and in a special sense to those who receive the sacrament of Holy Orders. In the case of both Christ himself and the Church's membership, however, the concept of priesthood is fundamentally associated with human nature, both soteriologically and anthropologically considered: human persons have at once a need for a salvation that can come only from Christ and a corresponding need to give fitting worship to God that likewise finds its fulfillment in Christ alone. The concept of priesthood, concretized and perfected in the priesthood of Christ, provides for the actualization of these same dimensions of human nature.Beginning with his treatment of Christ's priesthood in the tertia pars of the Summa theologiae (ST), in the first part of this essay I will explore the [End Page 789] broader systematic context in which Aquinas's account of Christ's priesthood should be understood, focusing in particular on the necessity of sacra doctrina and the Incarnation for the salvation of human nature, and the specific capacity of human nature for sacrificial, and ultimately priestly, acts in relation to God. Following this, in the second section I will examine the figural role of Christ's priesthood under the Mosaic Law. Although the Church now lives in the full reality of what was only foreshadowed in the Old Law, Aquinas's description of the figurative sense of this law—which is surprisingly rich—gives us a picture of the full ecclesial implications of Christ's priesthood in relation to the people that Aquinas describes in his systematic treatment of Christ's priesthood in ST III. Perhaps because of the correspondence between its literal sense and the scope of the natural law, the figurative treatment of Christ's priestly role in relation to the Church that is found in these questions on the Old Law provides a profound account of the elevation of human nature in the context of Christ's offering. First in outward ritual actions and then within human nature itself, Christ's realization of what is held in figure under the Old Law's letter offers a powerful account of the personal and social implications of Christ's singular sacrifice, understood as an offering made first in his humanity, and subsequently in ours by participation.Lastly, in my third and final section, I will return to priesthood within the Church as it is described in the tertia pars, exploring the baptismal priesthood and the ordained priesthood in relation to the priesthood of Christ. In each of these three sections, the divinizing relationship between the assumed humanity of Christ and the humanity of those who participate in his body will remain a point of emphasis, contextualized accordingly in each section. Beginning from the heart of Aquinas's sapiential treatment of Christ's priesthood in relation to the reality of the Incarnation, I hope to show not only that these same principals are reflected in Aquinas's treatment of Old Testament figures, but that the figurative dimension of these previous epochs of salvation history in fact provide a living illustration of Christ's priestly relationship with human nature in the context of the Church—because Christ is a priest, something foreshadowed in the Old Law and in the law of nature itself is fulfilled, and the image of God is restored in the rational creature.Christ's PriesthoodIn ST III, q. 22, a. 1, Aquinas offers a general definition of the priesthood, in the context of his description of the priesthood of Jesus Christ: "The office proper to a priest is to be a mediator... (shrink)

ABSTRACT This essay argues that science education can gain from close engagement with the history of science both in the training of prospective vocational scientists and in educating the broader public about the nature of science. First it shows how historicizing science in the classroom can improve the pedagogical experience of science students and might even help them turn into more effective professional practitioners of science. Then it examines how historians of science can support the scientific education of the general (...) public at a time when debates over “intelligent design” are raising major questions over the kind of science that ought to be available to children in their school curricula. It concludes by considering further work that might be undertaken to show how history of science could be of more general educational interest and utility, well beyond the closed academic domains in which historians of science typically operate. (shrink)

This paper follows the history of an object. The purpose of doing so is to come to terms with a distinctive kind of research object – which we are calling a ‘test object’ – as well as to chronicle a significant line of research and technology development associated with the broader nanoscience/nanotechnology movement. A test object is one of a family of epistemic things that makes up the material culture of laboratory science. Depending upon the case, it can have variable (...) shadings of practical, mathematical and epistemic significance. Clear cases of test objects have highly regular and reproducible visible properties that can be used for testing instruments and training novices. The test object featured in this paper is the silicon 7×7, a particular surface configuration of silicon atoms. Research on this object over a period of several decades has been closely bound up with the development of novel instruments for visualizing atomic structures. Despite having little direct commercial value, the Si 7×7 also has been a focal object for the formation of a research community bridging industry and academia. It exhibits a complex structure that became a sustained focus of observation and modelling. Our study follows shifts in the epistemic status of the Si 7×7, and uses it to re-examine familiar conceptions of representation and observation in the history, philosophy and social study of science. (shrink)

The aim of this virtual special issue is to bring together philosophical and historical perspectives to address long-standing issues in the interpretation, utility, and impacts of quantitative genetics methods and findings. Methodological approaches and the underlying scientific understanding of genetics and heredity have transformed since the field's inception. These advances have brought with them new philosophical issues regarding the interpretation and understanding of quantitative genetic results. The contributions in this issue demonstrate that there is still work to be done integrating (...) old and new methodological and conceptual frameworks. In some cases, new results are interpreted using assumptions based on old concepts and methodologies that need to be explicitly recognised and updated. In other cases, new philosophical tools can be employed to synthesise historical quantitative genetics work with modern methodologies and findings. This introductory article surveys three general themes that have dominated philosophical discussion of quantitative genetics throughout history: (1) how methodologies have changed and transformed our knowledge and interpretations; (2) whether or not quantitative genetics can offer explanations relating to causation and prediction; and (3) the importance of defining the phenotypes under study. We situate the contributions in this virtual special issue within a historical framework addressing these three themes. (shrink)

Curbside ethics consultations occur when an ethics consultant provides guidance to a party who seeks assistance over ethical concerns in a case, without the consultant involving other stakeholders, conducting his or her own comprehensive review of the case, or writing a chart note. Some have argued that curbside consultation is problematic because the consultant, in focusing on a single narrative offered by the party seeking advice, necessarily fails to account for the full range of moral perspectives. Their concern is that (...) any guidance offered by the ethics consultant will privilege and empower one party’s viewpoint over—and to the exclusion of—other stakeholders. This could lead to serious harms, such as the ethicist being reduced to a means to an end for a clinician seeking to achieve his or her own preferred outcome, the ethicist denying the broader array of stakeholders input in the process, or the ethicist providing wrongheaded or biased advice, posing dangers to the ethical quality of decision-making. Although these concerns are important and must be addressed, we suggest that they are manageable. This paper proposes using conflict coaching, a practice developed within the discipline of conflict management, to mitigate the risks posed by curbside consultation, and thereby create new spaces for moral discourse in the care of patients. Thinking of curbside consultations as an opportunity for clinical ethics conflict coaching can more fully integrate ethics committee members into the daily ethics of patient care and reduce the frequency of ethically harmful outcomes. (shrink)

This article examines Richard Lynch’s metaphysics and finds that he ultimately resolves his account of being in terms of essens—that which denotes the essential structure that a being (ens) has apart from existence. For Lynch, unlike many of his Jesuit contemporaries, existence is accidental to being. Yet, even if essens is distinct from existence, it is not altogether lacking being, but is accorded a certain kind of “essential being,” which is identified with the possible. Lynch thus seems (...) to re-appropriate an essentialist metaphysics that has antecedents in Avicenna and Henry of Ghent’s notion of esse essentiae. More proximate to Lynch is the Jesuit thinker Francesco Albertini, who takes Henry’s metaphysics and conveys it to Baroque Scholasticism. Lynch continues down that metaphysical path which, as we shall see, generated fierce controversy among late seventeenth-century Scholastics regarding the nature of creaturely possibility. (shrink)

Michael Polanyi and H.M. Collins contrast tacit knowledge with explicit knowledge. For Collins, secrets and other forms of “relational tacit knowledge” are tacit, but only in relation to specific circumstances and relationships. Collins treats such relational knowledge as less interesting theoretically than collective knowledge that is essentially difficult and perhaps impossible to convey through explicit formulations. In this paper I focus on relational tacit knowledge, despite its marginality in Collins’s typology, because it draws attention to conceptual ambiguities in the relationship (...) between tacit and explicit knowledge. More importantly, such ambiguities come into play as strategic resources in historical labor conflicts and in efforts to secure and preserve professional autonomy. Instead of treating tacit knowledge as a substantive possession of individuals and groups, I suggest that an empirical sociological alternative is to investigate pragmatic and polemical uses of the tacit/explicit distinction in particular circumstances of action and conflict. (shrink)

During the early Islamic period Cyprus was a frontier territory unlike most—control, influence, and tax revenue over the island were shared mutually by both the Byzantine and Islamic states—and the historiographical record demonstrates that its legal and administrative status was fraught with challenges. The present study is based on the surviving Arabic material in Abū ʿUbayd al-Qāsim b. Sallām’s Kitāb al-Amwāl, subsequently transmitted in Kitāb Futūḥ al-buldān of al-Balādhurī. It argues that the problematic nature of Cyprus in this period, coupled (...) with Abū ʿUbayd’s unprecedented access to genuine correspondence of jurists from the end of the eighth century, led the author to enshrine important documentary evidence that did not survive elsewhere. Furthermore, it suggests that the continued source-critical and comparative analysis of early Arabic narrative source material can still yield fruitful information for an understanding of the earliest centuries of Islamic history despite the sources’ many limitations. (shrink)

Todd McGowan is professor of film studies at the University of Vermont and author of The Impossible David Lynch and Capitalism and Desire: The Psychic Cost of Free Markets. This most...

A continuoxis t- norm is a continuous map * from [0, 1]² into [0,1] such that is a commutative totally ordered monoid. Since the natural ordering on [0,1] is a complete lattice ordering, each continuous t-norm induces naturally a residuation → and becomes a commutative naturally ordered residuated monoid, also called a hoop. The variety of basic hoops is precisely the variety generated by all algebras, where * is a continuous t-norm. In this paper we investigate the structure of the (...) variety of basic hoops and some of its subvarieties. In particular we provide a complete description of the finite subdirectly irreducible basic hoops, and we show that the variety of basic hoops is generated as a quasivariety by its finite algebras. We extend these results to Hájek's BL-algebras, and we give an alternative proof of the fact that the variety of BL-algebras is generated by all algebras arising from continuous t-norms on [ 0,1] and their residua. The last part of the paper is devoted to the investigation of the subreducts of BL- algebras, of Gödel algebras and of product algebras. (shrink)

Miguel A. De La Torre rejects hope as the ethical basis for a politically effective and truly liberative form of solidarity. Kelly Brown Douglas, on the other hand, articulates a critical retrieval of hope emphasizing the interpretive relationship between the cross, the lynching tree, and the resurrection. Reading De La Torre and Douglas’s works through Natalie Carnes’s theological aesthetics suggests that their respective works can be engaged as “iconoclasms of fidelity,” or the salutary breaking of idolatrous images toward recovering faithful (...) ones. Examining #SprayTheirNames murals that were created in response to state violence against Black people in the United States, I argue that Carnes’s aesthetics framework holds the violence of the crucifixion and promise of resurrection in visual tension, thus decrying violent oppression while offering a beautiful and dangerous memory that catalyzes hope-filled movement in defense of Black lives. (shrink)

A simplified definition of point local clocks and the relationship between an inertial reference frame and a class of such clocks, at rest with respect to each other, are used for an algebraic determination of the geometry of Minkowski's space-time on the set of point events. The group of all automorphisms that preserve the time ordering induced by the set of all equivalent local clocks is shown to be generated by the inhomogeneous orthochronous Lorentz group and dilatations, consistently with a (...) well-known result of E. C. Zeeman. The existence of a universal limit velocity and of an invariant clock cone through any event is among the implications of our proof, thus effectively exploiting a suggestion due to F. Severi. (shrink)

What might a synaesthetic cinema look like? Or, better, what might it sound, smell, taste and feel like? This essay approaches David Lynch's Mulholland Drive as a means of thinking through conceptual but concrete descriptions of synaesthesia not as an artistic device, a metaphor, an historical trend, or a rare clinical condition, but as a way of being in space and time — and being in cinema — that is simultaneously abstract and very real. Lynch's film becomes, as (...) well, an opportunity to think about cinematic spectacle and ‘excess’ in sensorily specific ways. The hallucinatory sensual disjunctions that occur throughout the film reveal a double system of reference: vision and proprioception mutually informing and interrupting one another, in ways that recall Brian Massumi's discussion of topological architecture. Those moments of cinematic, sensory ‘excess’ are sensual reminders of the degree to which vision is entangled with other senses in the experience of cinema. (shrink)

Our sense of self includes awareness of our thoughts and movements, and our control over them. This feeling can be altered or lost in neuropsychiatric disorders as well as in phenomena such as “automatic writing” whereby writing is attributed to an external source. Here, we employed suggestion in highly hypnotically suggestible participants to model various experiences of automatic writing during a sentence completion task. Results showed that the induction of hypnosis, without additional suggestion, was associated with a small but significant (...) reduction of control, ownership, and awareness for writing. Targeted suggestions produced a double dissociation between thought and movement components of writing, for both feelings of control and ownership, and additionally, reduced awareness of writing. Overall, suggestion produced selective alterations in the control, ownership, and awareness of thought and motor components of writing, thus enabling key aspects of automatic writing, observed across different clinical and cultural settings, to be modelled. (shrink)

This paper explores the possibilities for strategic maneuvering of the argumentative technique that Perelman and Olbrechts-Tyteca (The New Rhetoric. A Treatise on Argumentation, University of Notre Dame Press, Notre Dame/London, 1969) called dissociation. After an exploration of the general possibilities that dissociation may have for enhancing critical reasonableness and rhetorical effectiveness, the use of dissociation in the successive stages of a critical discussion is examined. For each stage, first, the dialectical moves that dissociation can be employed in are specified, then, (...) the specific ways in which dissociation contributes to fulfilling the dialectical tasks that are associated with these moves are delineated, and, finally, the rhetorical gain that␣dissociation can bring in the fulfillment of these tasks is discussed. Some general conclusions are drawn for research that aims at understanding the potential of an argumentative technique for strategic maneuvering. (shrink)

In this article, the pragma-dialectical model of a critical discussion is demonstrated to provide a useful instrument for discovering causes of an unsatisfactory development of problem-solving discussions. First a sketch is given of the development of a problem-solving discussion which, in the opinion of the participants themselves, developed in an unsatisfactory fashion. Then it is argued that this development can be traced back to flaws in the execution of the stages of a critical discussion.

The intersection of ethics, religion, theology, and peace studies is intensifying through increasingly multi‐disciplinary, contextual, explicitly normative scholarship. This book discussion demonstrates this claim through its profiles of an introduction to Christian ethics by Ellen Ott Marshall, a case study of the School of the Americas Watch by Kyle B. T. Lambelet, a case study of the American Jewish Palestine solidarity movement by Atalia Omer, and a global, historical study of Christian ethics by Cecilia Lynch. Though their methods and (...) subjects vary, these authors are collectively renewing a history of mutual enrichment between religious ethics and peace studies, employing theories of lived, ambivalent religion. To begin, this essay provides introductory remarks about the field of peace studies, highlighting the evolving involvement of religious actors. To conclude, it makes a plea for greater use of conflict theory and peace practice in religious ethics. (shrink)

Background: Discussing treatment risks has become increasingly important in medical communication. Still, despite regulations, physicians must decide how much and what kind of information to present. Objective: To investigate patients’ preference for information about a small risk of a complication of colonoscopy, and whether medical and personal factors contribute to such preference. To propose a disclosure policy related to our results. Design: Vignettes study. Setting: Department of Gastroenterology, Academic Medical Centre, the Netherlands. Patients: 810 consecutive colonoscopy patients. Intervention: A home-sent (...) questionnaire containing three vignettes. Vignettes varied in the indication for colonoscopy, complication severity and level of risk. Patients were invited to indicate their wish to be informed and the importance of such information. In addition, sociodemograhic, illness-related and psychological characteristics were assessed. Main outcome measurements: Wish to be informed and importance of information. Results: Of 810 questionnaires, 68% were returned. Patients generally wished to be informed about low-risk complications, regardless of the indication for colonoscopy or the severity of the complication. The level of risk did matter, though (OR = 2.48, SE = 0.28, p = 0.001). The information was considered less important if done for population screening purposes or diagnosis of colon cancer, if the complication was less severe (bleeding) and if the risk was smaller (0.01% and 0.1%). Patients’ information preference was also related to age, mood and coping style. Limitations: Difficulty of vignettes. Conclusions: Patients generally wish to be informed about all possible risks. However, this might become uninformative. A stepwise approach is suggested. (shrink)

Objectives: Efficient procedures for obtaining informed (proxy) consent may contribute to high influenza vaccination rates in nursing homes. Yet are such procedures justified? This study’s objective was to gain insight in informed consent policies in Dutch nursing homes; to assess how these may affect influenza vaccination rates and to answer the question whether deviating from standard informed consent procedures could be morally justified. Design: A survey among nursing home physicians. Setting & Participants: We sent a questionnaire to all (356) nursing (...) homes in the Netherlands, to be completed by one of the physicians. Results: We received 245 completed questionnaires. As 21 institutions appeared to be closed or merged into other institutions, the response was 73.1% (245/335). Of all respondents 81.9% reported a vaccination rate above 80%. Almost 50% reported a vaccination rate above 90%. Most respondents considered herd immunity to be an important consideration for institutional policy. Freedom of choice for residents was considered important by almost all. Nevertheless, 106 out of 245 respondents follow a tacit consent procedure, according to which vaccination will be administered unless the resident or her proxy refuses. These institutions show significantly higher vaccination rates (p < 0.03). Conclusions: In our discussion we focus on the question whether tacit consent procedures can be morally justifiable. Such procedures assume that vaccination is good for residents either as individuals or as a group. Even though this assumption may be true for most residents, there are good reasons for preferring express consent procedures. (shrink)

DNA double‐strand breaks (DSBs) are extremely hazardous lesions for all DNA‐bearing organisms and the mechanisms of DSB repair are highly conserved. In the eukaryotic mitotic cell cycle, DSBs are often present following DNA replication while, in meiosis, hundreds of DSBs are generated as a prelude to the reshuffling of the maternally and paternally derived genomes. In both cases, the DSBs are repaired by a process called homologous recombinational repair (HRR), which utilises an intact DNA molecule as the repair template. Mitotic (...) and meiotic HRR are managed by ‘checkpoints’ that inhibit cell division until DSB repair is complete. Here we attempt to summarise the substantial recent progress in understanding the checkpoint management of HRR in mitosis (focussing mainly on mammals) and then go on to use this information as a framework for understanding the presumed checkpoint management of HRR in mammalian meiosis. BioEssays 29:974–986, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

In this article, after arguing that present approaches to improving problem-solving discussions for various reasons are not satisfactory, I turn to the pragma-dialectic approach to argumentative discourse to derive a normative framework that can serve as a point of departure to enhance the quality of problem-solving discussions. I then show how this approach can be used as analytical and evaluative instrument that can help the analyst to establish whether participants in actual practice act in a fashion that is in accord (...) with the norms posited. Two real-life problem-solving discussions provide the material for this demonstration. (shrink)

"Hegel and the Foundations of Literary Theory: Do the various forms of literary theory - deconstruction, Marxism, new historicism, feminism, post-colonialism, and cultural/digital studies - have anything in common? If so, what are the fundamental principles of theory? What is its ideological orientation? Can it still be of use to us in understanding basic intellectual and ethical dilemmas of our time? These questions continue to perplex both students and teachers of literary theory. Habib finds the answers in theory's largely unacknowledged (...) roots in the thought of German philosopher Hegel. Hegel's insights continue to frame the very terms of theory to this day. Habib explains Hegel's complex ideas and how they have percolated through the intellectual history of the last century. This book will interest teachers and students of literature, literary theory and the history of ideas, illuminating how our modern world came into being, and how we can better understand the salient issues of our own time"--. (shrink)

If self-interested behavior conflicts with the collective welfare, rules of cooperation are often installed to prevent egoistic behavior. We hypothesized that installing such rules may instigate personal moral norms of cooperation, but that they fail in doing so when installed by a leader who is self-interested rather than self-sacrificing. Three studies confirmed this and also showed that, consequently, only self-sacrificing leaders were able to install rules that increase cooperation without the need for a perfectly operating monitoring system.